Genetic optimization for high-yield carotenoids #worldresearchawards


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Metabolic engineering of Escherichia coli has emerged as a powerful strategy for sustainable β-carotene production. By introducing and optimizing heterologous carotenoid biosynthetic pathways, researchers enhance precursor availability through the mevalonate (MVA) or methylerythritol phosphate (MEP) pathways. Key strategies include overexpression of rate-limiting enzymes, elimination of competing pathways, codon optimization, promoter engineering, and balancing metabolic flux to increase isoprenoid precursors such as IPP and DMAPP. Advanced tools like CRISPR-based genome editing, synthetic biology circuits, and systems-level metabolic modeling further improve yield and stability. Process optimization, including fermentation control and cofactor balancing, significantly boosts productivity. Engineered E. coli cell factories provide a cost-effective, scalable, and eco-friendly alternative to chemical synthesis and plant extraction, supporting applications in food, pharmaceuticals, cosmetics, and nutraceutical industries. 

#metabolicengineering #escherichiacoli #betacarotene #carotenoidbiosynthesis #syntheticbiology #microbialfactory #geneticengineering #biotechnology #isoprenoidpathway #industrialmicrobiology #bioprocessengineering #fermentationtechnology #crisprtechnology #metabolicflux #nutraceuticalproduction #biomanufacturing #systemsbiology #bioinnovation #greenbiotechnology #recombinantmicrobes 

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