The impact of metabolic reprogramming on disc cell senescence #sciencefa...







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Cellular senescence plays a crucial role in the pathophysiology of intervertebral disc degeneration (IDD), a major cause of chronic back pain and spinal disability. Senescent disc cells exhibit irreversible growth arrest, secrete pro-inflammatory cytokines, and contribute to matrix degradation, thereby accelerating tissue dysfunction. Understanding the molecular mechanisms underlying senescence—such as oxidative stress, DNA damage, mitochondrial dysfunction, and SASP activation—provides valuable insights into disc aging and degeneration. Therapeutic interventions, including senolytic drugs, gene editing, antioxidant therapy, and stem cell transplantation, offer promising avenues to modulate senescence, restore disc homeostasis, and delay degenerative progression. This review explores emerging evidence on targeting cellular senescence for intervertebral disc regeneration and highlights future directions for translational and clinical applications.

#sasp #senolytictherapy #oxidativestress #inflammationawareness #stemcell #regenerativemedicine #spinalhealth #biomechanics #microRNA #biomedicalresearch #cellularpathways #biomarkers #genetherapy #celltherapy #sciencefather #chinascientist #trending #technology#factsvideo
 
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